But generally it is still used for short-term use. Studies in recent years have shown that its half-life is 17 hours, so it can be taken as an intermediate-effect sulfa drug, and it can be administered twice a day. The disadvantage of sulfadiazine is that it is easier to precipitate crystals in the urinary tract, so it is necessary to take sodium bicarbonate together. Those who are resistant to this product can be treated with penicillins. If you eat dairy products, Ballya can also perform a sulfonamides test to tell you if there are sulfonamides residues in them. The drug-resistant strains have increased (20% reported domestically and 33% reported resistance to this product abroad). However, in recent years, meningococci are resistant to sulfadiazine and other sulfonamides. It is the first choice for the treatment of epidemic meningitis. The advantages of sulfadiazine are high effective concentration in the blood, low serum protein binding rate and easy penetration into the cerebrospinal fluid. Sulfadiazine has inhibitive effects for Streptococcus hemolyticus, Staphylococcus, Meningococcus, Pneumococcus, Neisseria gonorrhoeae, Escherichia coli, Shigella and other sensitive bacteria, as well as Chlamydiatrachomatis, Actinomyces, Plasmodium, Nocardia stellate, Toxoplasma and other organisms. Then, therefore it inhibits the growth and reproduction of bacteria. It can compete with PABA in bacteria, which prevents PABA as a raw material to synthesize folic acid required by bacteria, and reduces the amount of metabolically active tetrahydrofolate, which is an essential substance used by bacteria to synthesize purines, thymines and deoxyribonucleic acid (DNA). The molecular structure of sulfadiazine is similar to p-aminobenzoic acid (PABA). It is also called sulfadiazine and diazepam. Sulfadiazine is a sulfonamide commonly used clinically in China at present. After the reaction, the excess sulfadiazine cannot be recycled, so the cost of waste disposal is relatively high. In production, in order to increase the utilization rate of the more expensive silver nitrate, it is usually necessary to increase the amount of sulfadiazine by about 10%. The current production method of sulfadiazine silver salt is to react sulfadiazine powder with silver nitrate to produce sulfadiazine silver salt. In addition to the infection of burn wounds, it can also be used for the treatment of bedsore wounds, local frostbite, MRSA-infected ulcers and chronic cheilitis.
Silver sulfadiazine cream for dogs hot spots skin#
It is clinically effective in controlling, preventing, and killing Pseudomonas aeruginosa, as well as promoting wound healing, skin grafting, and regeneration. It is mainly used as an external medicine for the treatment of burn wounds.
It has the astringent effect of silver and the antibacterial and anti-inflammatory effect of sulfadiazine. Silver sulfadiazine is a compound of sulfadiazine and silver nitrate. What are the side effects of silver sulfadiazine?.Pharmacological effects of silver sulfadiazine.
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